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Tuesday, October 7, 2008

Hiding magnets in blood brings scans into focus

SURGEONS about to perform delicate operations on the heart or major blood vessels need the clearest pictures they can get. Magnetic nanoparticles injected into the bloodstream will help reveal fine details on MRI (magnetic resonance imaging) scans - but there's a snag. The particles quickly accumulate in the liver, which then removes them from the body.

Now Mauro Magnani of the University of Urbino in Italy and his team have found a way to get the tiny particles to spend longer in the bloodstream, by hiding them inside living red blood cells.

To do this, the team first immerse the blood cells in a watery solution, which causes them to swell. This opens pores in their membranes, allowing nanoparticles to drift into the cells. They become trapped when the cells are returned to a solution more like blood and the pores close up again (Journal of Nanoscience and Nanotechnology,
Source : technology.newscientist.com

Radar helmet could steer rescuers through smoke

Rescue workers must sometimes navigate smoke-filled and unfamiliar buildings. But helmets packed with sensors and software designed to give robots a sense of direction could build instant maps to help with a mission.

A technique called simultaneous location and mapping (SLAM) gives robots a version of the human ability to build up mental maps of an area as it is explored. The technique can be useful to, for example, let robotic cars navigate on unfamiliar streets.

As a robot moves, distance sensors and cameras measure and record the distances to surrounding objects, making it possible to build a detailed and accurate map of the area.

Burcu Cinaz at the University of Bremen in Germany and Holger Kenn at the European Microsoft Innovation Center, Achen, Germany, reasoned that the same technology could help humans navigate when visibility is reduced.

Wobbly walk

"Under heavy smoke, neither [a rescue worker's] own vision nor information captured by cameras is sufficient for localisation and mapping," says Kenn. "However, there are technologies available that can penetrate smoke." Radar and ultrasound are two examples.

Cinaz and Kenn tested their idea by strapping an infrared laser scanner to a helmet, and wearing it while strolling down the corridor outside their office (see image, top right). But the pair quickly encountered a problem.

The SLAM software they had loaded onto a laptop connected to the helmet was designed for sensors gliding steadily along on wheels, and also needs a precise record of distances travelled to build an accurate map.

But a walking person sways from side to side and their head bobs up and down, adding noise to the laser scanner signal. And there is no easy way to record the distance a person travels.

Scale error

"We tried to get away with a rather simple correction for head motion," says Kenn. The researchers added an inertia-measuring device near to the laser scanner to record how much the person's head swayed.

This makes it possible to factor out confusing signals and have the laser scanner record a relatively steady stream of data. The revised version of the software also assumes a person is walking at a constant speed.

The results are impressive – the software creates a map that accurately captures the shape of the area covered (see image, right). But so far the scale is always too small.

Kenn thinks the solution could be to combine his approach with the work of Stéphane Beauregard at the University of Bremen. "He has developed more advanced motion and position estimation for pedestrians," he says. They combine a head-mounted sensor with a second one mounted on the foot.

source : technology.newscientist.com

Physics Nobel snubs key researcher

Three particle physicists who provided insights into how tiny violations in symmetry shape the universe share this year's Nobel prize in Physics – but the decision has already sparked controversy.

Two Japanese researchers, Makoto Kobayashi and Toshihide Maskawa, share half the prize for explaining, in 1972, how the laws of physics apply to matter and antimatter in subtly different ways. Their discovery of the origin of broken symmetry predicts the existence of at least three families of quarks.

Some physicists have protested about the award.

According to the Italian newspaper La Repubblica, Roberto Petronzio, president of the Italian Institute for Nuclear Physics (INFN) is bitter at the omission of Nicola Cabibbo from the honour. Cabibbo's research laid the ground work for Kobayashi and Maskawa.

Building blocks

The other half of the prize goes to Japanese physicist Yoichiro Nambu who, in 1960, developed a theoretical framework called spontaneous symmetry breaking that describes how the forces of nature came into being shortly after the big bang.

Nambu’s mathematics paved the way for the standard model of particle physics, our best understanding of the building blocks of matter and the forces that act between them.

His ideas are behind the idea that the strong, electromagnetic and weak forces of nature were originally part of one superforce at the start of the universe. Spontaneous symmetry breaking is the mechanism by which this force broke apart to form three separate forces as the universe cooled.

Experiments at the Large Electron Positron Collider at the CERN laboratory in Geneva in the 1990s have tested spontaneous symmetry breaking to high accuracy, confirming that the electromagnetic and weak forces are different sides of the same electroweak force.

Secrets of mass

The same symmetry breaking concept was used in 1964 by physicists Peter Higgs, Robert Brout and François Englert to explain how the simplest chunks of matter acquire mass.

Their work showed how spontaneous symmetry breaking destroyed the symmetry between the forces and gave particles their mass. Their theory also predicts the existence of the hitherto-unseen Higgs boson, which is one of the main goals for physicists working on the Large Hadron Collider, CERN’s newest accelerator.

Anti-antimatter bias

Kobayashi and Maskawa's work helps to explain why the laws of physics are different for matter and antimatter.

Equal amounts of matter and antimatter were created shortly after the big bang. By rights, these should have annihilated each other leaving only radiation.

To create the matter-dominated universe we see today, there must be an imbalance in the laws of physics. The first evidence for such a bias was revealed in 1964, in studies of particles called kaons.

These are made of a quark and an antiquark, and can transform into their antimatter partners before decaying into other particles. Experiments revealed that kaons sometimes decay in a way that is forbidden if matter and antimatter obey the same rules.

More and more quarks

The findings threatened the standard model as it stood in the early 1970s.

Kobayashi and Maskawa found that the solution was to introduce three extra quarks, in addition to the up, down and strange quarks that were known at the time. The charm, bottom and top quarks were found a few years later.

Kobayashi and Maskawa also predicted that the same bizarre decays observed in kaons should also show up in experiments with particles built from heavier quarks.


source : technology.newscientist.com

Online bank customers create damaging 'silent runs'

The ease with which technology allows customers to move their money around by internet or phone has introduced a new financial phenomenon – the "silent run" on a bank.

Within hours, telephone and internet banking customers can remove huge amounts of money from a bank rumoured to be in trouble, without telltale queues, or any other outward sign of the flood of cash.

The bank Fortis, focus of a cross-border rescue by Benelux governments last week, was in part a victim of a silent bank run. That, along with a dramatic fall in its stock prompted an emergency cash injection of 11.2 billion euros and the Dutch government to fully nationalise the bank's Netherlands operations.

In the Great Depression between 1929 and 1933, much of the damage was caused by runs on banks that gained momentum as people saw lines of customers waiting to salvage cash. In Fortis's case, much of the outflow came at the click of a mouse.

'Banana republic'

The bank said it lost about 3% of its deposits from consumer and business clients, or about 5 billion euros ($7 billion).

British bank Northern Rock suffered the first run on a major British bank for more than 140 years last September, with panicked customers lining up at branches over three days. Scenes one politician said made Britain look like "a banana republic".

But branch withdrawals quickly slowed after the UK government guaranteed savings. The most serious damage was done by internet, postal and telephone withdrawals that continued to flood away. By the end of 2007, more than half the bank's retail deposits were gone – only a third via branches.

The silent online run may spare banks the damaging PR of queues outside branches. But funds can be moved more quickly and in far larger quantities with the click of a mouse or a telephone call.

Damaging speed

The speed at which that happens is one of the concerns behind recent scrambles by European governments to increase guarantees on deposits. Ireland and Denmark have offered blanket guarantees to savers, and pressure is mounting on others to follow as savers rush to put their cash in these safe havens.

Executives say that in any silent run the most damaging aspect is the speed at which business customers can move.

"The so-called silent run on the bank – it's real," says Carlos Evans, an executive at fourth-largest US bank Wachovia. The troubled bank is soon to be bought by a rival in a government-backed rescue plan.

Evans said withdrawals started picking up on September 26 and over subsequent days. "You go from being weakened to in trouble in a matter of days. I don't think people understand how quickly events unfolded," he says.


source: technology.newscientist.com

Invention: Aviation special

Man truly took to the air for the first time 105 years ago this December, setting off a chain of innovation that made human flight normal and even made space flight possible.

This week New Scientist's weekly patent column looks at the new ideas that could take the world of aviation and spacecraft to new heights.

Storm drones

Accurately predicting the path of a hurricane is a tricky task and finding a way to look inside the evolving storm is the main problem.

Radar sensors provide limited data about the internal features of a storm, and satellite photos are not taken regularly enough to make detailed predictions. Getting hold of low-altitude information, particularly from the eye of a hurricane is especially difficult.

Now defence company Raytheon in Waltham, Massachusetts, wants to send unmanned aerial vehicles (UAVs) on patrol inside the calm eye of hurricanes to get the information needed to improve forecasts.

The drones would stay in the eye, an area typically a few tens of kilometres across, for hours or days at a time. From there they could collect low-altitude data on the "eye wall" – the area of towering clouds where a hurricane's most severe weather is to be found.

To do that, however, the drones must know their eye wall from their elbow. So Raytheon is patenting an "eye wall sensor" that uses radar to sense the intense thunderstorm and rain activity that define the zone. Drones can then stay well clear of the dangerous areas, while collecting and transmitting valuable data.

Read the fullhurricane eye-wall detector patent application

Space fuel-tanker

Perhaps the most significant limit on the lifespan of a satellite is the amount of fuel it can carry for its thrusters. Once that is used up, the satellite has no way to maintain its orbit and must be abandoned, regardless of its mechanical health.

One proposed solution is to send space tankers into orbit that refill satellites using a pipe connection. But aerospace giant Boeing has spotted a problem with this idea.

The free space in a satellite's emptying fuel tank contains fuel vapour that must be squeezed out for it to be refilled. But if that vapour is dumped into space it will form a cloud around the satellite and tanker that can damage solar panels and other instruments.

Boeing has a simple solution: connect two pipes to the fuel tank when refuelling. One delivers the new fuel, and the other collects the vapour. That can be taken back to earth by the tanker, while the refuelled satellite enjoys a new lease of life.

Read the full space tanker patent application.

Amphibious commuter aircraft

As cities grow and become more crowded, commuting and travel of all kinds becomes more difficult. Flying in particular is getting ever more arduous, because airports must be situated at some distance from most cities, making journeys to and from them long and complex.

Russell Belden from Seattle thinks small, tri-hulled amphibious aircraft are the answer.

Traditional amphibious aircraft are little more than conventional aircraft with floats instead of wheels, he says. That causes all kinds of problems, according to Belden. The floats have poor aerodynamic qualities that make the aircraft slow and inefficient in the air, and also generate lots of spray on takeoff and landing that damages engines and control surfaces.

Belden has patented a design with floats he claims produce only minimal spray, and are highly aerodynamic.

In addition, the aircraft's wings fold up to allow the aircraft to dock in places other planes cannot reach – perfect for crowded city harbours. The inventor says his tri-hulled amphibious aircraft could revolutionise the city commute, at least in areas with lakes or reservoirs.

source: technology.newscientist.com

Mini microscope captures live brain-cell action

A microscope small enough to be mounted to the head of a freely moving mouse makes it possible to watch brain cell activity and whole animal behaviour simultaneously in mice. The device offers researchers a new way to study of human diseases using transgenic mice.

Since researchers created the first transgenic mice in the 1980s, the mouse has become the lab animal of choice for medical research. There are now mouse "models" for a wide range of human genetic disorders, from Parkinson's to asthma.

But correlating the activity inside cells with the behaviour of an animal as a whole is still a challenge, says Mark Schnitzer at Stanford University.

Cell spotter

"A lot of work has been done using brain slices, or anaesthetised animals – even using animals that are awake but restrained," he says. But so far it has been impossible to image cellular-level activity in a freely moving mouse.

Schnitzer's team has now made it possible. They designed a tiny microscope weighing just 1.1 grams that can be worn by a mouse without significantly impairing its movement. The device has already been used to study the circulation of blood through the one-cell-wide capillaries in the brain of active mice.

The microscope is attached to the head of a mouse under anaesthetic, while a marker dye is injected into the brain to label blood plasma, but leave blood cells unaffected. The microscope uses light delivered by a mercury arc lamp through a bundle of optical fibres.

Light from the lamp causes the dyed blood plasma to fluoresce, showing up individual blood cells as dark spots. The image is sent back up the fibre-optic bundle to a camera that records the image.

Roughly 100 images are taken every second, allowing the researchers to watch high-speed video of individual blood cells flowing in the brain. Once the mouse wakes up from the anaesthetic, it is possible to watch the movement of cells as it behaves normally.

Limited range

Using the technique with a dye that makes the activity of brain cells visible, the researchers could see how Purkinje neurons, involved in controlling movement, become more active when a mouse is moving than when resting.

"The advance here is we are able to look at cells in [moving] animals and we can do this in mice – the mammalian species of choice from the perspective of having advanced genetic techniques," says Schnitzer. "So we can look at mouse disease models and see what the cells are doing at the same time as we monitor what the mouse is doing."

Carl Petersen at the Swiss Federal Institute of Technology in Lausanne, Switzerland, is also interested in studying cellular activity in active mice. "It is a good advance," he told New Scientist, but the approach can't look at all kinds of brain activity.

The main problem, says Petersen, is that the brain scatters light extensively and so Schnitzer's technique can only capture images of cells near to the microscope. He also points out that the microscope lacks optical sectioning capability, a technique used to examine the internal 3D structure of tissue.

But Schnitzer says the lack of optical sectioning is beneficial because it renders the microscope less sensitive to motion artifacts caused by the moving animals.


Source : technology.newscientist.com

Multi-drug 'polypill' finally to tackle heart problems

Tests of a single, cheap tablet combining a range of drugs that protect against heart disease and stroke have begun.

The "polypill" was mooted years ago as a cheap way to slash deaths from the big killer diseases, but pharmaceutical companies were reluctant to take on the project as the inexpensive drugs involved provided no financial incentive.

Now a team funded by the Wellcome Trust in London, UK, and the British Heart Foundation, and led by Anthony Rodgers at the University of Auckland, New Zealand, has begun recruiting 700 volunteers in six countries for a pilot trial of a polypill manufactured by Dr Reddy's of Hyderabad, India.

Their Red Heart Pill, which costs just $1 for a month's supply, blends blood-thinning aspirin, a cholesterol-lowering statin, and an ACE inhibitor and a thiazide to lower blood pressure. Trials in thousands of people could start next year.

The polypill is aimed at reducing the risk of heart disease and stroke in poor and rich countries alike. However, its use will vary around the world, says Simon Thom of Imperial College London, who is running the UK trials.

In the developing world, he advocates distributing the pill "almost blind" to everyone over 55. But countries where people have better access to doctors and drugs are unlikely to adopt the one-size-fits-all approach. Instead, over-55s could be put on one of several different polypills containing varying doses of the drugs, depending on their health needs.


source : www.newscientist.com

Kanye West Says 'Love Lockdown' Video Was Inspired By 'American Psycho'

Kanye West Says 'Love Lockdown' Video Was Inspired By 'American Psycho'

Rapper also explains what led him to write his book, 'Thank You and You're Welcome.'

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After Kanye West unveiled the new video for his single "Love Lockdown" on "The Ellen DeGeneres Show" on Tuesday (October 7), he admitted that the clip's modern look was inspired by a chainsaw-wielding maniac.

"On this album, I kind of embody Patrick Bateman from 'American Psycho,' " he joked on the show, adding, "You know at the end of the movie [that] he didn't really kill anyone. [I just liked] the clean aesthetic and the way he was all about labels. I wanted to express all of that in the video."

The rapper, who sings on the single, explained that he was ready to try a different direction on the upcoming album 808s and Heartbreak, which was recently slated for a November 25 release. "I had all these ideas and I just needed to get it out as an artistic vision," he said. "I don't have a rapper's name, [but] I have really good taste and anyone who likes it probably has really good taste too."

In addition to opening up about his late mother, Donda West, the rapper also talked a bit about his unlikely turn as an author and the philosophy behind his book, "Thank You and You're Welcome."

"I wanted to come up with a theory that applies to my life in 2008, not someone else's thousands of years ago. I wanted to make a book for non-readers, like myself," he said. "I only read when necessary, so me and my friend designed this book."

The "Love Lockdown" video, which DeGeneres deemed "brilliant," can be seen on her official Web site.

Source : mtv.com

Eminem Is The Best Rapper Alive, According To Vibe Poll

Eminem Is The Best Rapper Alive, According To Vibe Poll

MC, who has been very quiet in recent years, still beat out Jay-Z, Kanye West, Game, Ludacris in mag's readers' poll.

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According to Vibe magazine's fans, Lil Wayne isn't "The Best Rapper Alive." He isn't even in the top two. After weeks of online voting, Eminem was crowned the globe's top MC in a tournament-style contest.

In a contest on the magazine's Web site, 64 of today's top rappers — from MTV News' reigning "Hottest MC in the Game" Kanye West toRick Ross, Nas and T.I. — were given brackets, similar to NCAA basketball teams during March Madness. Fans began voting on head-to-head matchups in July, with MCs gradually being eliminated until Marshall Mathers was tapped as the ultimate victor this month, beating out Brooklyn lyric guru Jay-Z. Slim Shady received 69 percent of the votes in the finals. The magazine said more than 920,000 votes were cast.

(What do you think of the results of Vibe's poll? Sound off in the Newsroom blog!)

"It's obviously an honor to have won the fans' support by being voted the Best Rapper Alive," Em said in a statement released Tuesday (October 7). "I don't think that there is any one rapper that is simply the best, though. Everyone who was in consideration and many others are the best at certain things, and at what they do. But since Vibe's offering the distinction, hell yeah, I'll accept!"

"Vibe is thrilled we could put the debate about the Best Rapper Alive in the hands of the fans," the mag's music editor, Sean Fennessey, said. "Eminem isn't just one of the most successful MCs of all time, he's also one of the most beloved. The proof is in the voting."

Vibe will be rolling out Eminem's win in their November 2008 issue. Presidential hopeful Barack Obama will grace the cover of that issue.

The win comes after several years of near-silence from Eminem. Most of his public speaking has been done on his satellite radio station Shade 45 during brief, lighthearted interviews. Eminem appeared on the show a couple of weeks ago, telling listeners he's been focusing on his own material. During a press run for the movie "Righteous Kill," Em's most well-known signee, 50 Cent, said he was in Em's Detroit home studio working on tracks for his next album Before I Self Destruct. Dr. Dre was also revealed to be working with the two. 50's album is slated for release on December 9; no release date or title has been announced for Eminem's next project.

Source :mtv.com

50 Cent Drops 'Get Up,' The First Track From Before I Self Destruct

50 Cent Drops 'Get Up,' The First Track From Before I Self Destruct

Plus: Tony Yayo says G-Unit might tour with Lil Wayne after all.

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Rise and shine! The G-Unit General says there's no lying down on the job. 50 Cent just released "Get Up," the first record from his upcoming Before I Self Destruct LP.

"Trust me, homie, I'm not playing/ I'll have the dance floor off the chain," 50 promises on the record. He also gives his word to make "every other week feel like Mardi Gras."

"You dudes better follow instructions/ I said, 'Get up,' " he adds over the pounding bass.

Fif released the track on ThisIs50.com, and it immediately started getting play on New York radio.

A few days ago, 50 told Blender magazine that he was still in Detroit working on Self Destruct with Eminem. He said they had at least one song called "Norman Bates Motel" completed.

"Dre sent over a bunch of beats, and we're just going through them all, picking out who wants what," 50 told the mag. "We already finished one joint and just started vocals on another. It's gonna blow you away, I guarantee."

While 50 is in the lab recording, he's also contemplating a major outing. "We was slated to do a 52-date tour, but our schedule got crazy," G-Unit member Tony Yayo told MTV News. "So I guess on Self Destruct, we should be doing a big tour."

50's right-hand man hinted that the G-Unit/Lil Wayne tour talked about several months ago might be resurrected.

"That'd be cool man," Yayo said. "Lil Wayne is a big artist. I'd love to be on a tour with Lil Wayne. It would be an issue. I actually spoke to Wayne a couple of months ago on the phone, him and Baby. They some cool n---as. I'm happy for the boy [Weezy]. What he did was make people wanna go hard again, because it's possible you can do them big numbers that first week."


Source : MTV.com